I7661-39N
Integrin, beta1 (CD29, Very Late Antigen, VLAb1, Platelet gplla) (Azide Free)
Größe
£819.00
- SKU:
- I7661-39N
- Reinheit:
- Purified by Protein A affinity chromatography.
- Lagerbedingungen:
- -20°C
- Hersteller:
- United States Biological
- Host:
- Mouse
- Klon:
- 2Q842 (P4C10)
- Format:
- Supplied as a liquid in PBS, pH 7.6. No preservative added.
- Weitere Details:
- Integrin beta 1, also known as CD29, is a 130 kDa transmembrane glycoprotein that forms noncovalent complexes with various Integrin alpha subunits (including alpha 1, alpha 2, alpha 3, alpha 4, alpha 5, and alpha 6) to form the functional receptors that bind to specific extracellular matrix proteins. Integrin receptors are involved in the regulation of a variety of important biological functions, including embryonic development, wound repair, hemostasis, and prevention of programmed cell death. They are also implicated in abnormal pathological states such as tumor directed angiogenesis, tumor cell growth, and metastasis. These heterodimeric receptors bridge the cytoplasmic actin cytoskeleton with proteins present in the extracellular matrix and/or on adjacent cells. Interactions between integrins and the extracellular matrix lead to activation of signal transduction pathways and regulation of gene expression. Applications: Suitable for use in ELISA, Immunocytochemistry/Immunoflourescence, Immunoprecipitation, Western Blot and Functional Assays. Other applications not tested. Recommended Dilutions: Functional Assays: 1:50-1:500, inhibits attachment of UCLA-P3 cells to collagen type I (Wayner, 1991). Inhibits endodermal and keratinocytes to collagen, fibronectin and laminin. It also inhibits cell to cell adhesion. Optimal dilutions to be determined by the researcher. Control: Human Tonsil, human skin, human lung, liver, and skeletal muscle tissues Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
- Versandbedingungen:
- Blue Ice