Hypoxia Inducible Factor 1b (HIF-1b, ARNT, Aryl hydrocarbon Receptor Nuclear Translocator) (Not for Export EU)

Größe

£704.00

SKU:: H9808-02
Reinheit:: Serum
Lagerbedingungen:: -20°C
Hersteller:: United States Biological
Host:: Rabbit
Immunogen:: Fusion protein corresponding to human HIF-1 beta containing amino acids 496-789.
Format:: Supplied as a liquid, 0.02% sodium azide
Weitere Details:: Hypoxia contributes significantly to the pathophysiology of major categories of human disease, including myocardial and cerebral ischemia, cancer, pulmonary hypertension, congenital heart disease and chronic obstructive pulmonary disease. HIF-1, a nuclear protein activating gene transcription in response to reduced cellular 02 concentration, activates the transcription of VEGF, EPO, iNOS, heme oxygenase 1 and other intracellular responses critical to hypoxia. HIF-1 is a heterodimer composed of HIF-1a and HIF-1b subunits. HIF-1 a most closely resembles the Drosophila protein Sim. HIF-1 b is a series of aryl hydrocarbon receptor nuclear translocator (ARNT) gene products. (1,5,6) Cellular Localization: HIF-1 beta is a nuclear protein. Positive Control: MCF7 human nuclear extracts Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.