G2037-05D
Glial Fibrillary Acidic Protein (GFAP, FLJ45472)
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£709.00
- SKU:
- G2037-05D
- Reinheit:
- Purified by Protein G affinity chromatography from tissue culture supernatant.
- Lagerbedingungen:
- -20°C
- Hersteller:
- United States Biological
- Host:
- Mouse
- Immunogen:
- Bovine spinal cord homogenate.
- Klon:
- 4A11
- Format:
- Supplied as a liquid in PBS, 0.09% sodium azide.
- Weitere Details:
- Glial fibrillary acidic protein, or GFAP, is a class III intermediate filament. During development of the central nervous system, GFAP distinguishes astrocytes from other glial cells. It is involved in various cellular functions, such as cell structure and movement, cell communication and the functioning of the bloodbrain barrier. It also plays a role in mitosis by adjusting the filament network present in the cell. Defects in GFAP are a cause of Alexander disease, a rare disorder of the central nervous system affecting mostly males. It is a progressive leukoencephalopathy resulting in mental and physical retardation, dementia, seizures and early death. May be used in conjunction with 214854 and 214855 for increased sensitivity when used in immunohistology. Applications: Suitable for use in Western Blot, Immunohistochemistry and RIA. Other applications have not been tested. Recommended Dilutions: Western Blot: 1:500-1:10,000 Immunohistochemistry: Frozen and paraffin sections. Requires protein digestion pretreatment of paraffin sections e.g. trypsin or pronase. Optimal dilutions to be determined by the researcher. Positive Control for Immunohistochemistry: Brain Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
- Versandbedingungen:
- Blue Ice