F9200-01A
Furin (Dibasic-processing Enzyme, PACE, Paired Basic Amino Acid Residue-cleaving Enzyme, FUR, PACE, PCSK3)
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£537.00
- SKU:
- F9200-01A
- Anwendung:
- IHC-Fr
- Reinheit:
- Purified by Protein A affinity chromatography.
- Lagerbedingungen:
- -20°C
- Hersteller:
- United States Biological
- Host:
- Rabbit
- Immunogen:
- Synthetic peptide corresponding to aa740-790 of human Furin. Species sequence homology: chicken and xenopus.
- Format:
- Supplied as a liquid in PBS, 0.05% BSA, 0.05% sodium azide.
- Weitere Details:
- Furin, also known as Paired basic aa residue cleaving enzyme, is a 794aa containing membrane associated protein circulating between the trans-Golgi network and cell surface. It belongs to the peptidase S8 family and Furin subfamily with a homo B/P domain. Known to represent the ubiquitous endoprotease activity within constitutive secretory pathways, Furin, a calcium-dependent serine endoprotease, can efficiently cleave precursor proteins at their paired basic aa processing sites (RX (K/R) R consensus motif). This proprotein convertase enzyme processes latent precursor proteins into their biologically active products and is important in the release of albumin and complement component C3 from their respective precursors and in the physiologic processing of proparathyroid hormone, von Willebrand factor, insulin receptor, TGF1B, hepatocyte growth factor, C propeptide of collagen type V, alpha 1, NOTCH signaling proteins, certain viral envelope glycoproteins and ED1. Ubiquitous expression of Furin is seen in most of the tissues. It may also play a role in tumor progression and maintainance of immune tolerance. Applications: Suitable for use in Immunohistochemistry. Other applications not tested. Recommended Dilution: Immunohistochemistry (formalin fixed paraffin embedded): 5ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
- Versandbedingungen:
- Blue Ice