F6002-62D
FNBP1 (Formin Binding Protein 1, Formin-binding Protein 1, FBP1, Formin Binding Protein 17, FBP17, hFBP17, KIAA0554, MGC126804)
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£642.00
- SKU:
- F6002-62D
- Reinheit:
- Purified by immunoaffinity chromatography.
- Lagerbedingungen:
- -20°C
- Hersteller:
- United States Biological
- Host:
- Goat
- Immunogen:
- Synthetic peptide corresponding to KQLESSKRRFERDC, from human FNBP1, at the internal region of the protein (NP_055848.1).
- Format:
- Supplied as a liquid in Tris saline, pH 7.3, 0.5% BSA, 0.02% sodium azide.
- Weitere Details:
- FBP17, a 71kD microtubule binding protein, is a member of Formin binding protein family. It consists of a CIP4 homology (FCH) domain at the N-terminus, followed by first coiled-coil domain, a proline rich motif, a second coiled-coil domain, a Rho family protein-binding domain (RBP) and a C-terminal SH3 domain. FBP17 binds to dynamin with its FCH domain and induces tubular membrane invaginations thereby participating in dynamin-mediated endocytosis. It also interacts with Rho family GTPases and Snx2, a protein involved in EGFR signaling and plays a significant role during cytoskeleton organization, cell polarity and signal transduction. Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilution: ELISA: 1:32,000 Western Blot: 0.25-2ug/ml, observed in human testis lysates on ~70kD bands Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
- Versandbedingungen:
- Blue Ice