D9300-20
DR3, NT (Wsl-1, Apo-3, TRAMP, LARD, Death Receptor3)
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£655.00
- SKU:
- D9300-20
- Reinheit:
- Purified by DEAE chromatography.
- Lagerbedingungen:
- -20°C
- Hersteller:
- United States Biological
- Host:
- Rabbit
- Immunogen:
- Synthetic peptide corresponding to 16aa from the N-terminus of human DR3. Epitope: first 50aa.
- Format:
- Supplied as a liquid in PBS, 0.02% sodium azide.
- Weitere Details:
- Apoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain containing receptors, TNFR1 and Fas. A novel cell death receptor was recently identified by several groups independently and designated DR3, Wsl-1, Apo-3, TRAMP and LARD. The ligand for this novel death receptor has been defined as TWEAK, also termed Apo3L. DR3 is highly expressed in the tissues enriched in lymphocytes including PBL, thymus and spleen. Like TNFR1, DR3 induces apoptosis and NF-kB activation. Applications: Suitable for use in ELISA, Immunofluorescence and Western Blot. Other applications have not been tested. Recommended DilutionS: Western Blot: 1:500-1:1000. A band at ~59kD can be seen with Jurkat whole cell lysate. Optimal dilutions to be determined by researcher. Positive Control: Jurkat whole cell lysate. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
- Versandbedingungen:
- Blue Ice