Dopamine Receptor, D4

Größe

£869.00

SKU:: D9018-10
Reinheit:: Purified by affinity chromatography.
Lagerbedingungen:: -20°C
Hersteller:: United States Biological
Host:: Rabbit
Immunogen:: Peptide corresponding to 10aa from within the 3rd extracellular domain of mouse Dopamine Receptor, D4. No significant homology with other dopamine receptors (D1, D2, D3 or D5). Species Sequence Homology (90%): human and rat
Format:: Supplied as a liquid in PBS, 0.1% BSA.
Weitere Details:: Mouse Dopamine receptor D4 is a 387 aa, G-protein coupled and transmembrane receptor protein (1). This gene encodes the D4 subtype of the dopamine receptor. The D4 subtype is a G-protein coupled receptor which inhibits adenylyl cyclase. It is a target for drugs which treat schizophrenia and Parkinson disease. Mutations in this gene have been associated with various behavioral phenotypes, including autonomic nervous system dysfunction, attention deficit/hyperactivity disorder, and the personality trait of novelty seeking. This gene contains a polymorphic number (2-10 copies) of tandem 48 nt repeats; the sequence shown contains four repeats. Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilutions: ELISA: 0.5-1ug/ml (1ug/ml immnogen peptide/well) Western Blot: 1-10ug/ml using chemiluminescence technique. ~100-400ug of membrane protein/lane should be loaded to visualize the receptor band. Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Versandbedingungen:: Blue Ice