Diaphanous 1 (hDia1, DIAPH1, p140DIA, DFNA1, LFHL1, diaphanous homolog 1, DRF1, Diaphanous-related formin 1, LFHL1, low frequency hearing loss 1, deafness, autosomal dominant 1)

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£642.00

SKU:: D3470-01B
Reinheit:: Purified by peptide affinity chromatography.
Lagerbedingungen:: -20°C
Hersteller:: United States Biological
Host:: Goat
Immunogen:: Synthetic peptide corresponding to C-QTKTSKAKKDQ, from the internal region of human Diaphanous 1 (NP_005210.3; NP_001073280.1).
Format:: Supplied as a liquid in Tris saline, pH 7.3, 0.5% BSA, 0.02% sodium azide.
Weitere Details:: This gene is a homolog of the Drosophila diaphanous gene, and has been linked to autosomal dominant, fully penetrant, nonsyndromic sensorineural progressive low-frequency hearing loss. Actin polymerization involves proteins known to interact with diaphanous protein in Drosophila and mouse. It has therefore been speculated that this gene may have a role in the regulation of actin polymerization in hair cells of the inner ear. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. Applications: Suitable for use in ELISA and Western Blot. Other applications have not been tested. Recommended Dilutions: Peptide ELISA Titer: 1:32,000 Western Blot: 0.3-1ug/ml ~140kD band observed in lysates of cell line NIH3T3 (calculated MW of 141kD according to Human NP_005210.3 and 139kD according to Mouse NP_031884.1). Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Versandbedingungen:: Blue Ice