C8370
CXCR4, NT (Fusin, LESTR, HUMSTR, C-X-C Chemokine Receptor 4, CD184)
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£479.00
- SKU:
- C8370
- Reinheit:
- Purified by immunoaffinity chromatography.
- Lagerbedingungen:
- -20°C
- Hersteller:
- United States Biological
- Host:
- Goat
- Immunogen:
- Synthetic peptide TEEMGSGDYDSMKEPCFREENANFNKC corresponding to N-terminal extracellular domain of human CxCR4 receptor.
- Format:
- Supplied as a liquid in PBS, pH 7.2, 1mg/ml BSA, 0.09% sodium azide.
- Weitere Details:
- CD184, otherwise known as CXCR4 (C-X-C chemokine receptor type 4), is a transmembrane glycoprotein and member of the G-protein coupled receptor 1 family, ubiquitously expressed in blood and tissue cells, which acts as a specific receptor for the chemokine SDF-1 (Stromal cell-derived factor 1). Interaction of CD184 with SDF-1 mediates the chemotaxis of progenitor and mature blood cells, and is critical for B- lymphopoiesis and myelopoiesis. CD184 is a major co-receptor for infection by T-cell tropic strains of HIV1, and also a primary receptor for some HIV2 isolates. . Applications: Suitable for use in ELISA, Western Blot, and Immunohistochemistry. Other applications not tested. Recommended Dilution: Immunohistochemistry (paraffin): 1:150 ELISA: 1:25,000 Western Blot: 1:250 Optimal dilutions to be determined by the researcher. Positive Control: Spleen Storage and Stability: May be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
- Versandbedingungen:
- Blue Ice