C8299-05
CX3CR1 (Beta Chemokine Receptor-like 1, CCRL1, Chemokine C-X3-C Motif Receptor 1, CX3C Chemokine Receptor 1, C-X3-C CKR-1, CX3C CKR-1, CMK-BRL-1, CMKBLR1, CMKDR1, Fractalkine Receptor, GPR13, GPRV28, V28)
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£655.00
- SKU:
- C8299-05
- Reinheit:
- Purified by Immunoaffinity chromatography.
- Lagerbedingungen:
- -20°C
- Hersteller:
- United States Biological
- Host:
- Rabbit
- Immunogen:
- Synthetic peptide corresponding to 20 amino acids near the N-terminus of mature human CX3CR1. Epitope: within first 50aa. Species Sequence Homology: bovine (82%)
- Format:
- Supplied as a liquid in PBS, 0.02% sodium azide.
- Weitere Details:
- CX3CR1 is one of the chemokine receptors that are required as coreceptors for HIV infection. The genes encoding human, murine, and rat CX3CR1 were cloned and designated V28 and CMKBRL1, CX3CR1, and RBS11, respectively. The encoded seven transmembrane protein was recently identified as the receptor for a novel transmembrane molecule, fractalkine, and renamed CX3CR1. Recently, CX3CR1 was found to serve as a coreceptor for HIV-1 and HIV-2 envelope fusion and virus infection, which can be inhibited by fractokine. CX3CR1 mediates leukocyte migration and adhesion. CX3CR1 is expressed in a variety of human tissues and cell lines. Applications: Suitable for use in ELISA, Immunohistochemistry, Immunofluorescence, Flow Cytometry and Western Blot. Other applications not tested. Recommended Dilutions: Immunohistochemistry (Paraffin): 2ug/ml, Requires antigen retrival using heat treatment prior to staining of paraffin sections. Sodium citrate buffer pH 3.0 is recommened for this purpose. Western Blot: 1-2ug/ml. Detects a band of ~50kD in human spleen cell lysates. Immunofluorescence: 10-20ug/ml Flow Cytometry: 0.1ug/ml Optimal dilutions to be determined by the researcher. Immunohistochemistry Positive Control: Human heart Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
- Versandbedingungen:
- Blue Ice