C7907-09-APC

C-Reactive Protein (CRP, MGC88244, PTX 1, PTX1) (APC)

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£869.00

SKU:: C7907-09-APC
Anwendung:: FLISA
Reinheit:: Purified by Protein A affinity chromatography. Purity is tested by electrophoresis (> 90%).
Lagerbedingungen:: 4°C Do Not Freeze
Hersteller:: United States Biological
Host:: Mouse
Immunogen:: Purified Human CRP
Klon:: 1.BB.97
Format:: Supplied as a liquid in PBS, pH 7.2. Labeled with Allophycocyanin (APC).
Weitere Details:: C-reactive protein (CRP) is an acute phase reactant. CRP is released by the body in response to acute injury, infection, or other inflammatory stimuli. Recent development of a high sensitivity assay for CRP (hs-CRP) has enabled investigation of this marker of systemic inflammation. CRP and Atherosclerosis: Atheromatous plaques in diseased arteries typically contain inflammatory cells. Rupture of atheromatous plaque is thought to be the mechanism for acute myocardial infarction and acute coronary syndrome. The most common site of plaque rupture appears to be the shoulder region where inflammatory cells are most prominent. Thus the release of acute phase reactants as a response to inflammation have been proposed as a potential marker of an "unstable" atheromatous plaque and underlying atherosclerosis. Studies have shown a positive association between CRP and coronary artery disease. In a survey of 388 British men aged 50-69, the prevalence of coronary artery disease increased 1.5 fold for each doubling of CRP level (1). Multiple prospective studies demonstrated that baseline CRP is a good marker of future cardiovascular events (2). It has been suggested that CRP may be a good marker of cardiovascular risk in addition to lipid level. Applications: Suitable for use in CRP immunoassay and immunoaffinity purification, and as coating/tracer antibody in FLISA. Other applications have not been tested. Recommended Dilution: FLISA: > 10e-6 (Titer) Optimal dilutions to be determined by the researcher. Hybridoma: Sp 2/0 myeloma cells with spleen cells from Balb/c mice. Matched Pair: Suitable for use as the capture or solid phase antibody. Matched to C7907-10 or C7907-11, C7907-04Q as the detection or conjugate (label) antibody. Capture: C7907-09 Storage and Stability: May be stored at 4°C before opening. DO NOT FREEZE! Stable at 4°C as an undiluted liquid. Dilute only prior to immediate use. Stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer. Allophycocyanin (APC) is light sensitive. Note: Applications are based on unconjugated antibody.

Versandbedingungen:: Blue Ice