C7906-75

Cranin (Dystroglycan)

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£767.00

SKU:: C7906-75
Reinheit:: Ascites
Lagerbedingungen:: -20°C
Hersteller:: United States Biological
Host:: Mouse
Immunogen:: Synthetic peptide corresponding to aa572-604 of human Cranin.
Klon:: 2Q36
Format:: Supplied as a liquid.
Weitere Details:: Cranin is expressed in brain and many other tissues, it binds laminin with high affinity in a calcium dependent manner. It appears to be important in maintaining normal muscle integrity. Loss of cranin from the muscle surface may be one of the primary events leading to muscle injury in congenital muscular dystrophies, it may also play a role in the cognitive deficits often seen in such conditions. Applications: Suitable for use in ELISA, Immunohistochemistry and Immunocytochemistry. Not recommended for use in Western Blot. Other applications not tested. Recommended Dilutions: Immunohistochemistry: 1:1-1:50 detects Cranin on tissue fixed briefly with 0.5% glutaraldehyde, 4% paraformaldehyde, methanol or acetone. Prolonged fixation must be avoided. Immunocytochemistry: Neuron, astrocyte, smooth muscle, fibroblast and epithelial cell lines. Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.