C2777-83
C18 Ceramide (N-Stearoyl-D-sphingosine, Stearoyl Ceramide)
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£435.00
- SKU:
- C2777-83
- Molekulargewicht:
- 565.95
- Lagerbedingungen:
- -20°C
- Hersteller:
- United States Biological
- CAS Number:
- 2304-81-6
- Format:
- White solid
- Weitere Details:
- The sphingolipid ceramide is a potent inhibitor of the mitochondrial permeability transition poreand a primary short-chain ceramide found in brain tissue whose synthesis is regulated by longevity-assurance homologue 1 (Lass1) in mice. Increased expression of C18 ceramide reduces cell growth in UM-SCC-22A squamous cell carcinoma cells. It is selectively downregulated in 32 human head and neck squamous cell carcinoma tumor tissues as compared to non-squamous tumor tissues. C18 Ceramide concentration is significantly higher in muscle tissue of type 2 diabetic patients compared with non-diabetic patients and is positively correlated to body mass index and inversely related to insulin sensitivity. Synonyms: N-[(1S,2R,3E)-2-Hydroxy-1-(hydroxymethyl)-3-heptadecen-1-yl]octadecanamide; D-erythro-1,3-Dihydroxy-2-octadecanoylamido-trans-4-octadecene; N-Stearoyl-_x000B_C18-sphingosine; N-Stearoyl-D-erythro-sphingosine; N-Stearoyl-D-sphingosine; N-Stearoylsphingenine; N-Stearoylsphingosine CAS No: 2304-81-6 Molecular Formula: C36H71NO3 Molecular Weight: 565.95 Purity: ≥95% Appearance: White solid Melting Point: 99-101.5°C Solubility: Chloroform, Methanol (Sparingly), DMF Method for Determining Identity: Proton NMR and Mass Spectrometric Analysis TLC Conditions: SiO2; Dichloromethane: Methanol: 9:1; Visualized with AMCS and KMnO4; Single spot; Rf=0.60. Storage and Stability: May be stored at RT for short-term only. Long-term storage is recommended at -20°C. Stable for 6 months after receipt.
- Versandbedingungen:
- Ambient