CD82 (CT) (4F9,C33, GR15, Inducible membrane protein, Inducible membrane protein R2, KAI 1, KAI1, Kangai 1, Kangai1, Metastasis suppressor Kangai 1, R2, R2 leukocyte antigen, SAR2, ST6, Suppression of tumorigenicity 6, Suppression of tumorigenicity 6 prostate, Tetraspanin27, Tspan27) (HRP)

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£869.00

SKU:: C2433-60C-HRP
Reinheit:: Purified by immunoaffinity chromatography.
Lagerbedingungen:: -20°C
Hersteller:: United States Biological
Host:: Rabbit
Immunogen:: Synthetic peptide corresponding to 15aa sequence from near the C-terminus of human CD82.
Format:: Supplied as a liquid in PBS, pH 7.2. Labeled with horseradish peroxidase (HRP).
Weitere Details:: CD82 has been identified as a cancer metastasis suppressor protein, while ubiquitously expressed at moderate to high levels in many normal tissues, its expression is down regulated during tumor progression. Loss of CD82 and p53 is correlated with poor prognosis for patients with prostate and other forms of cancer. Research has demonstrated that CD82 interacts with CD234 (DARC). It has been hypothesized that tumor cells dislodged from the primary tumor and expressing CD82 interact with CD234 expressed on vascular cells, transmitting a senescent signal to the tumor cells. tumor cells that have lost CD82 expression can proliferate and potentially give rise to metastases. It has been demonstrated that at least two isoforms of CD82 exist. Applications: Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: Immunohistochemistry: Paraffin Optimal dilutions to be determined by the researcher. Immunohistochemistry Positive Control Tissue: Human colon Storage and Stability: Store product at 4°C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20°C. Aliquots are stable at -20°C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Note: Sodium azide is a potent inhibitor of peroxidase and should not be added to HRP conjugates. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Note: Applications are based on unconjugated antibody.

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