C2398-54A
CD44 (Phagocyte Glycoprotein 1, PGP-I, HUTCH-I, ECMR-III, Hermes Antigen, Hyaluronate Receptor, Heparan Sulfate Proteoglycan, Epican, MC56, MIC4)
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£590.00
- SKU:
- C2398-54A
- Reinheit:
- Purified by Protein G affinity chromatography.
- Lagerbedingungen:
- -20°C
- Hersteller:
- United States Biological
- Host:
- Rat
- Immunogen:
- Dexamethasone-induced cells of the SJL mouse spontaneous myeloid leukemia M1
- Klon:
- IM7
- Format:
- Supplied as a liquid in PBS, pH 7.4, 0.09% sodium azide
- Weitere Details:
- CD44 is a transmembrane glycoprotein expressed on the surface of most cells, which serves as a receptor for hyaluronan. CD44 mediates angiogenesis, cell adhesion, proliferation and migration, it is thus important for lymphocyte activation, recirculation and homing, it can thus serve e.g. as a modulator of macrophage recruitment in response to pathogen. Although CD44 functions are essential for physiological activities of normal cells, elevated CD44 expression correlates with poor prognosis in many carcinomas, facilitating tumor growth and metastasis, antiapoptosis and directional motility of cancer cells. Applications: Suitable for use in Western Blot, Flow Cytometry, Immunocytochemistry, Immunoprecipitation and Immunohistochemistry. Other applications not tested. Recommended Dilutions: Immunohistochemistry: Formalin fixed paraffin embedded or frozen sections Flow Cytometry: 1ug/ml Western Blot: Non-reducing conditions. Optimal dilutions to be determined by the researcher. Positive Controls: Flow Cytometry: mouse peripheral blood. Immunohistochemistry: mouse spleen Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
- Versandbedingungen:
- Blue Ice