C2383-02S
CD31 (PECAM-1, Platelet Endothelial Cell Adhesion Molecule, PECAM-1, EndoCAM, GPIIA', PECA1, CD31, PECAM1) (PE)
Größe
£607.00
- SKU:
- C2383-02S
- Anwendung:
- Flow Cytometry
- Reinheit:
- Purified by immunoaffinity chromatography.
- Lagerbedingungen:
- 4°C Do Not Freeze
- Hersteller:
- United States Biological
- Host:
- Goat
- Immunogen:
- NS0-derived recombinant protein corresponding to Glu18-Lys590 from mouse CD31.
- Format:
- Supplied as a liquid in sodium chloride, 0.5% BSA, 0.09% sodium azide. Labeled with R-Phycoerythrin (PE).
- Weitere Details:
- PECAM-1 (platelet endothelial cell adhesion molecule1; also known as CD31) is a 130kD type I transmembrane glycoprotein adhesion molecule in the immunoglobulin superfamily. Expression is restricted to cells involved in circulation, especially endothelial cells, platelets, monocytes, neutrophils, and lymphocyte subsets. PECAM-1 is concentrated at cell-cell junctions and is required for trans-endothelial migration (TEM). The extracellular domain (ECD) of PECAM-1 has ten potential N-linked glycosylation sites and six C2 type Ig like domains, the first of which is critical for adhesion and extravasation. The cytoplasmic domain contains immunoregulatory tyrosine-based inhibitory and switch motifs (ITIM, ITSM) that mediate both inhibition and activation via phosphotyrosine-mediated engagement of SH2-containing signaling molecules. Applications: Suitable for use in Flow Cytometry. Other applications not tested. Recommended Dilutions: Optimal dilutions to be determined by the researcher. Storage and Stability: Store product at 4°C in the dark. DO NOT FREEZE! Stable at 4°C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: PE conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
- Versandbedingungen:
- Blue Ice