C1150-02
Carboxyl Terminal Modulator Protein, Human (CTMP) Control Peptide
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£416.00
- SKU:
- C1150-02
- Reinheit:
- Highly purified
- Lagerbedingungen:
- -20°C
- Hersteller:
- United States Biological
- Format:
- Supplied as a liquid in PBS, pH 7.2
- Weitere Details:
- A 17-aa peptide sequence near the middle region of human CTMP (1) . Protein kinase B (PKB) is a major downstream target of receptor tyrosine kinases that signal via phosphatidylinositol 3-kinase (PIK3). Upon cell stimulation, PKB is translocated to the plasma membrane, where it is phosphorylated on thr308 in the catalytic domain and ser473 in the C-terminal regulatory domain. Several protein partners for PKB have been identified. CTMP, a carboxyl terminal modulator protein, binds to PKB-a and negatively regulates PKB activity by inhibiting phosphorylation of these PKB residues. CTMP (mouse 248-aa, human 240-aa, chromosome 1q21, 22-26kD) predominantly expressed in skeletal muscle, testis, uterus, brain, and kidney, with lower levels in heart, liver, and lung. The presence of multiple transcripts suggested that CTMP undergoes alternative splicing.
- Versandbedingungen:
- Blue Ice