C1150-01A
Carboxyl Terminal Modulator Protein (CTMP, Thioesterase Superfamily Member 4, THEM4) (Not for Export EU)
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£704.00
- SKU:
- C1150-01A
- Reinheit:
- Serum
- Lagerbedingungen:
- -20°C
- Hersteller:
- United States Biological
- Host:
- Rabbit
- Immunogen:
- Recombinant corresponding to human CTMP.
- Format:
- Supplied as a lyophilized powder from PBS, 0.05% sodium azide.
- Weitere Details:
- Protein kinase B (PKB) is a major downstream target of receptor tyrosine kinases that signal via phosphatidylinositol 3-kinase PIK3). Upon cell stimulation, PKB is translocated to the plasma membrane, where it is phosphorylated on thr308 in the catalytic domain and ser473 in the C-terminal regulatory domain. Several protein partners for PKB have been identified. CTMP, a carboxyl terminal modulator protein, binds to PKB and negatively regulates PKB activity by inhibiting phosphorylation of these PKB residues. CTMP (mouse 248aa, human 240aa, chromosome 1q21, 22-26kD) predominantly expressed in skeletal muscle, testis, uterus, brain, and kidney, with lower levels in heart, liver, and lung. The presence of multiple transcripts suggested that CTMP undergoes alternative splicing. Applications: Suitable for use in ELISA. Western Blot, though not tested, may potentially be used as an application. Other applications not tested. Recommended Dilution: Western Blot: 1:1000-1:5000 (Chemiluminescence) ELISA: 1:10,000-1:100,000; 50-100ng of control antigen/well Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. For long-term storage, store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
- Versandbedingungen:
- Blue Ice