B0807-50C
BCMA IgG2a Fc, Fusion Protein (B Cell Maturation Protein) (Biotin)
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£832.00
- SKU:
- B0807-50C
- Molekulargewicht:
- 33
- Reinheit:
- Purified by Protein A affinity chromatography.
- Lagerbedingungen:
- 4°C Do Not Freeze
- Hersteller:
- United States Biological
- Format:
- Supplied as a liquid in PBS.
- Weitere Details:
- The human B cell activating factor (BAFF) and APRIL(a proliferation inducing ligand) are both type II molecules belonging to the TNF superfamily. They are expressed by non-B cells, and are down-regulated by mitogenic stimulation.2 BAFF and APRIL bind to at least two receptors: TACI (transmembrane activator and CAML-interactor) and BCMA (B cell maturation antigen), both of which are restricted to B cells.3,4 Ligation of these receptors with recombinant BAFF dramatically increases IgM production by peripheral blood B cells 1. Recently a third receptor for BAFF (BAFF-R) was described.5 Cell surface BAFF can be cleaved to form a soluble trimeric molecule. 2BCMA-muIg binds to recombinant BAFF-muCD8 and can inhibit binding of this molecule to receptors on Raji cells. Molecular Structure: A soluble molecule consisting of the extracellular (54aa) domain of human BCMA fused to the murine IgG2a Fc (232 aa). Predicted monomeric weight: 33kD. Transfectant Cell Line: CHO Functional Application: BCMA-muIg binds to recombinant BAFF-muCD8 and can inhibit this molecule's abiltiy to bind to receptors on Raji cells. Applications: Suitable for use in ELISA. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C. For long-term storage, aliquot and store at 4°C. Do not freeze. Aliquots are stable for at least 6 months. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.
- Versandbedingungen:
- Blue Ice