Amyloid beta A4 Precursor Protein-Binding, Family B, Member 1 (APBB1, Fe65, MGC:9072, RIR, Adaptor Protein FE65a2, Stat-like Protein)

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£607.00

SKU:: A2275-61P2
Reinheit:: Purified by immunoaffinity chromatography.
Lagerbedingungen:: -20°C
Hersteller:: United States Biological
Host:: Rabbit
Immunogen:: Recombinant protein corresponding to rat FE65, expressed in bacteria. Cellular Localization: Cytoplasmic
Format:: Supplied as a liquid in PBS, 0.02% sodium azide, 15% glycerol.
Weitere Details:: FE65 is a signaling adaptor of APP protein. The FE65/APP complex was shown to translocate into the cell nucleus and regulate gene expression. Genetic studies in mice validated FE65-APP interaction and molecular studies provided evidence on the role of the complex in abnormal signaling detected in brains of Alzheimer Disease patients. Applications: Suitable for use in Western Blot and Immunoprecipitation. Other applications not tested. Recommended Dilutions: Western Blot: 1:1000, a band is seen at ~100kD versus the predicted molecular weight of 77kD, which corresponds to earlier findings in literature Immunoprecipitation: 2-10ug Optimal dilutions to be determined by the researcher. Positive Control: IMR32 neuronal cell lysate, HEK 293 cell lysate, or brain lysate Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.