ABCG1 (ATP-Binding Cassette (ABC) Sub-family G Member 1, AbC8, ATP-Binding Cassette Tansporter 8, White Protein Homolog, WHT1)

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£639.00

SKU:: A0004-12B
Reinheit:: Purified by peptide immunoaffinity chromatography.
Lagerbedingungen:: -20°C
Hersteller:: United States Biological
Host:: Rabbit
Immunogen:: A synthetic peptide made to an internal region of human ABCG1 (between residues 300-400).
Format:: Supplied as a liquid.
Weitere Details:: ATP-binding cassette (ABC) transporter genes are involved in the regulation of the amount of dietary cholesterol retained in the body. The ABC transporter ABCG1 (ABC8) is expressed on the cell surface and in intracellular compartments of cholesterol-laden macrophages and is induced in monocyte-derived macrophages during cholesterol influx mediated by acetylated low-density lipoprotein. In contrast, lipid efflux in cholesterol-laden macrophages, mediated by the cholesterol acceptor HDL(3), suppresses the expression of ABCG1. Applications: Suitable for use in Western Blo and Immunohistochemistry. Other applications not tested. Recommended Dilution: Western Blot: Theoretical molecular weight of ABCG1 is ~75.6kD, Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.