552896
DOC2
Größe
£607.00
- SKU:
- 552896
- Reinheit:
- Purified
- Lagerbedingungen:
- -20°C
- Hersteller:
- United States Biological
- Host:
- Mouse
- Immunogen:
- Purified recombinant protein fragment corresponding to aa652-749 from human DOC2, expressed in E. coli.
- Klon:
- 2H7C4
- Format:
- Supplied as a liquid in PBS, 0.05% sodium azide.
- Weitere Details:
- This gene encodes a mitogen-responsive phosphoprotein. It is expressed in normal ovarian epithelial cells but is down-regulated or absent from ovarian carcinoma cell lines suggesting its role as a tumor suppressor. This protein binds to the SH3 domains of GRB2 an adaptor protein that couples tyrosine kinase receptors to SOS (a guanine nucleotide exchange factor for Ras) via its C-terminal proline-rich sequences and may modulate growth factor/Ras pathways by competing with SOS for binding to GRB2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. Applications: Suitable for use in ELISA, Flow Cytometry, Western Blot and Immunocytochemistry. Other applications not tested. Recommended Dilutions: ELISA: 1:10,000 Flow Cytometry: 1:200-1:400 Western Blot: 1:500-1:2000 Immunocytochemistry: 1:200-1:1000 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
- Versandbedingungen:
- Blue Ice