Estradiol 3-(β-D-Glucuronide) (Sodium Salt)

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£276.00

SKU:: 505265
Molekulargewicht:: 470.5
Lagerbedingungen:: 4°C
Hersteller:: United States Biological
CAS Number:: 14982-12-8
Weitere Details:: Estradiol 3-(β-D-glucuronide) (E23G) is a non-cholestatic regioisomer of the estrogen metabolite, estradiol 17-(β-D-glucuronide) (E217G).1,2 It acts as a substrate for multidrug resistance protein 2 (MRP2; Km = 122 µM), competing with E217G for MRP2-mediated transport (IC50 = 14.2uM).2,3 E23G has been reported to inhibit E217G transport through rat organic anion-transporting polypeptide 1 with a Ki value of 9.7uM, but is a low-affinity inhibitor of both MRP4 and MRP7 (IC50s = ~100uM).2 Synonyms: (17β)-17-hydroxyestra-1,3,5(10)-trien-3-yl β-D-glucopyranosiduronic acid, monosodium salt, E23G, β-Estradiol 3-(β-D-Glucuronide), 17β-Estradiol 3-(β-D-Glucuronide), 17β-Oestradiol 3-(β-D-Glucuronide) CAS No: 14982-12-8 Molecular Formula: C₂₄H₃₁O₈•Na Molecular Weight: 470.5 Solubility: DMSO: 20mg/ml DMF: >10mg/ml Purity: ≥95% Appearance: Crystalline solid Storage and Stability: Store at 4°C. Hygroscopic. For maximum recovery of product, centrifuge the original vial prior to removing the cap.