TLR3, Recombinant, Human, aa23-704, His-Tag (Toll-Like Receptor 3)

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£607.00

SKU:: 470258
Molekulargewicht:: 47.4
Reinheit:: ≥90% (SDS-PAGE). Endotoxin: ≤1EU/ug (LAL).
Lagerbedingungen:: -20°C
Hersteller:: United States Biological
Format:: Supplied as a liquid in 20mM Tris-HCl, pH 8.0, 0.1M sodium chloride, 1mM DTT, 20% glycerol.
Weitere Details:: TLR3, also known as toll-like receptor 3, is a member of the toll-like receptor family which plays a fundamental role in pathogen recognition and activation of innate immunity. It is innate immune receptors for sensing microbial molecules and damage-associated molecular patterns released from host cells. It recognizes dsRNA and activation of the receptor induces the activation of NF-kappaB and the production of type I interferons (IFNs). Its signaling activation is associated with ischemic preconditioning-induced protection against brain ischemia and attenuation of reactive astrogliosis. It is most abundantly expressed in placenta and pancreas, and is restricted to the dendritic subpopulation of the leukocytes. Recombinant human TLR3, fused to His-Tag at C- terminal, expressed in insect cell and purified by using conventional chromatography techniques. Recombinant protein corresponding to aa23-704 from human TLR3, fused to His-Tag at C-terminal, expressed in Insect Cell. Molecular Weight: ~47.4kD (416aa) (confirmed by MALDI-TOF) Amino Acid Sequence: SSTTKCTVSH EVADCSHLKL TQVPDDLPTN ITVLNLTHNQ LRRLPAANFT RYSQLTSLDV QLSDKTFAFC TNLTELHLMS NSIQKIKNNP FVKQKNLITL DLSHNGLSST KLGTQVQLEN ELSSNQIKEF SPGCFHAIGR LFGLFLNNVQ LGPSLTEKLC LELANTSIRN LSLSNSQLST SFAWLPQLEY FFLEYNNIQH LFSHSLHGLF NVRYLNLKRS FTKQSISLAS LPKIDDFSFQ YLSLSNSFTS LRTLTNETFV SLAHSPLHIL NLTKNKISKI ESDAFSWLGH LEVLDLGLNE RNSFALVPSL QRLMLRRVAL KNVDSSPSPF QPLRNLTILD LSNNNIANIN DDMLEGLEKL HLHILNLESN GFDEIPVEVF KDLFELKIID LGLNNLNTLP ASVFNNQVSL KSLNLQKNLI SIAWFVNWIN ETHTNIPELS SHYLCNTPPH YHGFPVRLFD TSSCKDSAPF ELLEHHHHHH GFNTISKLEP ELCQKLPMLK VLNLQHNELS LQELLLSNNK IQALKSEELD IFANSSLKKL TSNTTFLGLK WTNLTMLDLS YNNLNVVGND WLKCLEHLNM EDNDIPGIKS NMFTGLINLK IGQELTGQEW RGLENIFEIY LSYNKYLQLT EILDLQHNNL ARLWKHANPG GPIYFLKGLS TSVEKKVFGP AFRNLTELDM RFNPFDCTCE Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing.. Store at -20°C. Aliquots are stable for 6 months after receipt at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Versandbedingungen:: Blue Ice