Guanabenz Acetate

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£364.00

SKU:: 451505
Molekulargewicht:: 291.33
Lagerbedingungen:: -20°C
Hersteller:: United States Biological
CAS Number:: 23256-50-0
Format:: Supplied as a Pale Yellow Solid
Weitere Details:: Guanabenz Acetate is an α-adrenoreceptor agonist that is used as an antihypertensive agent. A cell-permeable a2-adrenoceptor agonist that lowers protein misfolding in stressed cells (EC50 ~400nM in tunicamycin treated HeLa cells) and acts as a proteostatis regulator. Shown to selectively bind PPP1R15A/GADD34 and disrupt the PPP1R15A-PP1c complex; sustain eIF2a phosphorylation and increase chaperone availability by attenuating translation. Synonyms: [(2,6-Dichlorobenzylidene)amino]guanidine Monoacetate; 2-[(2,6-Dichlorophenyl)methylene]hydrazinecarboximidamide Monoacetate; 1-(2,6-Dichlorobenzylideneamino)guanidine Acetate; BR 750; Guanabenz Acetate; Guanabenz Monoacetate; Rexitene; Tenelid; Wy 8678 Acetate; Wytens; Wytensin; [(2,6-Dichlorobenzylidene)amino]guanidine Acetate CAS Number: 23256-50-0 Free Base: 5051-62-7 Molecular Formula: C₁₀H₁₂Cl₂N₄O₂ Molecular Weight: 291.33 Appearance: White to Pale Yellow Solid Melting Point: 187-189ºC Solubility: Acetone (Slightly), DMF (Slightly), DMSO (Slightly), Methanol (Slightly) Storage: Hygroscopic, -20°C Freezer, Under inert atmosphere