MBL2, Recombinant, Human, aa21-248, His-Tag (Mannose-Binding Protein C, MBL2, COLEC1, HSMBPC, MBL, MBL2D, MBP, MBP-C, MBP1, MBPD)

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£607.00

SKU:: 396903
Molekulargewicht:: 25.1
Reinheit:: ≥90% (SDS-PAGE)
Lagerbedingungen:: 4°C/-20°C
Hersteller:: United States Biological
Format:: Supplied as a liquid in PBS, pH 7.4, 10% glycerol.
Weitere Details:: MBL2, also known as mannose-binding protein C, belongs to the class of collectins in the C-type lectin superfamily. It is a lectin that is instrumental in innate immunity via the lectin pathway. It recognizes carbohydrate patterns, found on the surface of a large number of pathogenic micro-organisms, including bacteria, viruses, protozoa and fungi. It It binds senescent and apoptotic cells and enhances engulfment of whole, intact apoptotic cells, as well as cell debris by phagocytes. This protein has recently been found to play a role in development of type 1 diabetes and gestational diabetes mellitus. Also, mutant MBL2 haplotypes have been linked to disease progression and response to therapy in HCV infection. Recombinant human MBL2, fused to His-Tag at C-terminal, expressed in insect cell and purified by using conventional chromatography techniques. Source: Recombinant protein corresponding to aa21-248 of human MBL2, fused to His-Tag at C-terminal, expressed in insect cell. Molecular Weight: ~25.1kD (237aa), ~28-40kD (SDS-PAGE under reducing conditions) Endotoxin: <1EU/1ug (determined by LAL method) Amino Acid Sequence: ADPETVTCED AQKTCPAVIA CSSPGINGFP GKDGRDGTKG EKGEPGQGLR GLQGPPGKLG PPGNPGPSGS PGPKGQKGDP GKSPDGDSSL AASERKALQT EMARIKKWLT FSLGKQVGNK FFLTNGEIMT FEKVKALCVK FQASVATPRN AAENGAIQNL IKEEAFLGIT DEKTEGQFVD LTGNRLTYTN WNEGEPNNAG SDEDCVLLLK NGQWNDVPCS TSHLAVCEFP IHHHHHH Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing.. Store at -20°C. Aliquots are stable for 6 months after receipt at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Versandbedingungen:: Blue Ice