384977
Calcineurin A (CalcineurinA, Calmodulin Dependent Calcineurin A Subunit Alpha Isoform, Calmodulin-Dependent Calcineurin A Subunit Alpha Isoform, CALN, CALNA, CALNA 1, CAM PRP Catalytic Subunit, CCN 1, Protein Phosphatase 2B Catalytic Subunit Protein Phosphatase 3 (Formerly 2B) Catalytic Subunit Alpha Isoform, Protein Phosphatase 3 Catalytic Subunit Alpha Isoform PPP3CA, Protein Phosphatase 3 Catalytic Subunit Alpha Isozyme, Serine/Threonine Protein Phosphatase 2B Catalytic Subunit Alpha Isoform)
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£497.00
- SKU:
- 384977
- Reinheit:
- Purified by peptide affinity chromatography.
- Lagerbedingungen:
- -20°C
- Hersteller:
- United States Biological
- Host:
- Rabbit
- Immunogen:
- Synthetic peptide corresponding to aa264-283 of human Calcineurin A.
- Format:
- Supplied as a liquid in PBS, pH 7.4, 0.09% sodium azide, 50% glycerol.
- Weitere Details:
- Calcineurin is a heterodimeric phosphatase protein, also known as calcium-dependent serine-threonine phosphatase. The structure consists of a catalytic subunit alpha, Calcineurin A (57-59kD) the active site and a Ca2+ binding unit, Calcineurin B (19-20kD) the regulatory subunit (1). Calcineurin plays a key role in the T-cell response growth and differentiation mechanism, regulating the activation of the Nuclear factor of activated T-cells (NFATc) which are important in the expression of IL-2 genes. Calcineurin has been the target of inhibitors, the novel and structural immune-suppressants antifungal drugs (2). Genetic studies in yeast and fungi established the molecular basis of the inhibition mechanism by cyclosporine A and FK506 (3). Applications: Suitable for use in Western Blot, Immunocytochemistry/Immunofluorescence, Immunohistochemistry, Immunoprecipitation. Other applications not tested. Recommended Dilution: Western Blot: 1:1000 Immunocytochemistry/Immunofluorescence: 1:120 Immunohistochemistry: 1:100 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
- Versandbedingungen:
- Blue Ice