SHANK1/SHANK3 (Shank Postsynaptic Density Protein, SH3 Multiple Ankyrin Repeat Domains 3, Proline Rich Synapse Associated Protein 2, Proline-Rich Synapse-Associated Protein 2, ProSAP2, PSAP2, SH3, Multiple Ankyrin Repeat Domains Protein 3, SH3/Ankyrin Domain Gene 3, Shank3b, SPANK 2, SPANK2, KAP/SAPAP Interacting Protein, OTTHUMP00000174437, SH3, Multiple Ankyrin Repeat Domains 1, SH3, Multiple Ankyrin Repeat Domains Protein 1, SH3/Ankyrin Domain Gene 1, SHANK 1, Shank1, Shank1a, Somatostatin Receptor Interacting Protein, Somatostatin Receptor-Interacting Protein, SPANK 1, SPANK1, SSTR Interacting Protein, SSTR-Interacting Protein, SSTRIP, Synamon, AI841104, DEL22q13.3, KIAA1650)

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£626.00

SKU:: 384912
Reinheit:: Purified by Protein G affinity chromatography.
Lagerbedingungen:: -20°C
Hersteller:: United States Biological
Host:: Mouse
Immunogen:: Fusion protein corresponding to aa538-626 (SH3 domain) of rat SHANK3.
Klon:: S367-51
Format:: Supplied as a liquid in PBS, pH 7.4, 0.09% sodium azide, 50% glycerol.
Weitere Details:: SHANK proteins are scaffolding adaptors that have been shown to integrate neurotransmitter receptors into the cortical cytoskeleton at postsynaptic densities. SHANK1-3 of the SHANK/ProSAP family are molecular scaffolds in the postsynaptic density (PSD). SHANK recruits betaPIX and PAK to dendritic spines to regulate postsynaptic structure and interacts with ionotropic receptor and metabotropic glutamate receptor complexes. Transcript splice variation in the Shank family influences the spectrum of Shank-interacting proteins in the PSDs of adult and developing brain to ensure normal development. Applications: Suitable for use in Western Blot, Immunocytochemistry/Immunofluorescence, Immunohistochemistry. Other applications not tested. Recommended Dilution: Western Blot: 1:1000 Immunocytochemistry/Immunofluorescence: 1:100 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Versandbedingungen:: Blue Ice