PRMT9, Human, Recombinant, FLAG-Tag, Strep-Tag, aa2-845 (Protein Arginine Methyltransferase 9)

Größe

£990.00

SKU:: 377023
Molekulargewicht:: 97
Reinheit:: ≥83%
Lagerbedingungen:: -70°C
Hersteller:: United States Biological
Format:: Supplied as a liquid in 40mM Tris-HCl, pH 8.0, 110mM sodium chloride, 2.2mM potassium chloride, 0.04% Tween-20, 80ug/ml flag peptide, 20% glycerol.
Weitere Details:: PRMT9 (protein arginine methyltransferase 9) is a type II methyltransferase, as it generates SDMA (symmetrically di-methylated arginine). Arginine methylation of proteins is a common post-translational modification, particularly in RNA-binding proteins. PRMT9 contains two S-adenosylmethionine binding motifs and three TPRs (tetratricopeptide repeats). It is a modulator of the splicing factor SAP145/SAP149 complex. PRTM9 has increased activity in blast and leukemia stem cells (LSCs) derived from patients with AML (acute myeloid leukemia), indicating a potential role in cancer cell survival and proliferation. Indeed, PRTM9 inhibition increased DNA damage in these cells, and type I INF (interferon) response. The use of combinatory therapy of a PD-1 (programmed cell death protein 1)/PDL1 (programmed death-ligan 1) inhibitor with a PRTM9 inhibitor may prove beneficial in oncology. Additionally, the PRMT9/SAP415 axis was also implicated in autosomal recessive intellectual disability (ARID), bringing into light a new role of this protein. Recombinant protein corresponding to aa2-845 from human PRMT9, fused to N-terminal FLAG-Tag, C-terminal Strep-Tag, from SF9 Insect Cells. Molecular Weight: ~97kD Storage and Stability: Aliquot to avoid repeated freezing and thawing and store at -70°C. Aliquots are stable for 6 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Versandbedingungen:: Dry Ice