369616
PTPMT1 (Protein Tyrosine Phosphatase, Mitochondrial 1, PLIP, DUSP23, MOSP, PTEN-like phosphatase, Phosphoinositide lipid phosphatase, Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1)
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£626.00
- SKU:
- 369616
- Reinheit:
- Purified by immunoaffinity chromatography.
- Lagerbedingungen:
- -20°C
- Hersteller:
- United States Biological
- Host:
- Rabbit
- Immunogen:
- PTPMT1 (Met71~Val197)
- Format:
- Supplied as a liquid in PBS, pH 7.4, 0.02% sodium azide, 50% glycerol.
- Weitere Details:
- PTPMT1 is a recently discovered dual specificity phosphatase that has been implicated in the regulation of insulin secretion. Database analysis using the mouse ortholog, which encodes a deduced 261aa protein, revealed 60 orthologs from 4 different phylogenetic kingdoms that share more than 70% aa identity within the active site region. The active site sequence between aa128 and aa148 of mouse and human PLIP is identical. Northern blot analysis of several mouse tissues detected highest expression in testis. Plip showed activity against PtdIns(5)P that was 44-fold greater than that against PtdIns(3,5)P2, its second most preferred substrate, when the phosphoinositides were presented in a lipid bilayer with phosphatidylserine Applications: Suitable for use in ELISA, Western Blot, Immunoprecipitation, Immunohistochemistry, Immunocytochemistry. Other applications not tested. Recommended Dilution: ELISA: 1:100-1:5000 Western Blot: 1:50-400 Immunohistochemistry (frozen): 1:50-500 Immunohistochemistry (paraffin): 1:10-100 Immunocytochemistry: 1:50-500 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
- Versandbedingungen:
- Blue Ice