MASP1 (Mannose Associated Serine Protease 1, CRARF, PRSS5, Mannan-Binding Lectin Serine Peptidase 1, Ra-reactive factor serine protease p100, Complement-activating component of Ra-reactive factor, Serine protease 5)

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£524.00

SKU:: 369571
Reinheit:: Purified by immunoaffinity chromatography.
Lagerbedingungen:: -20°C
Hersteller:: United States Biological
Host:: Rabbit
Immunogen:: Recombinant protein corresponding to His20~Ala44 of MASP1 expressed in E. coli.
Format:: Supplied as a liquid in 0.01M PBS, pH 7.4, 0.05% Proclin-300, 50% glycerol.
Weitere Details:: Mannose-associated serine protease 1 (MASP1) is involved in the lectin pathway of the complement system and is responsible for cleaving C4 and C2 to form C4b2a, a C3-convertase.Mannose-binding lectin (MBL) is a serum component which participates in innate immunity by activating complement via a novel pathway. Human MBL forms complexes with two types of serine proteases termed MASP (MBL-associated serine protease). These two proteases, MASP1 and MASP2, are structurally similar to one another as well as to C1r and C1s. Together, MASP, C1r and C1s constitute a novel serine protease family. It is likely that human MASP1 is able to activate C3, while human MASP2 cleaves C4, although further functional studies are required to confirm this. Applications: Suitable for use in ELISA, Western Blot, Immunofluorescence Immunoprecipitation, Immunohistochemistry, Immunocytochemistry. Other applications not tested. Recommended Dilution: ELISA: 0.05-2ug/ml Western Blot: 1-5ug/ml Immunohistochemistry (frozen): 5-20ug/ml Immunohistochemistry (paraffin): 5-20ug/ml Immunocytochemistry: 5-20ug/ml ELISA: 0.05-2ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Versandbedingungen:: Blue Ice