HPS6 (Hermansky Pudlak Syndrome Protein 6, Ru, Ruby-eye Protein Homolog)

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£517.00

SKU:: 369547
Anwendung:: WB
Reinheit:: Purified by Protein A and peptide affinity chromatography.
Lagerbedingungen:: -20°C
Hersteller:: United States Biological
Host:: Rabbit
Format:: Supplied as a liquid in PBS, pH 7.4, 0.02% sodium azide, 50% glycerol.
Weitere Details:: In mice there are at least 16 naturally occurring hypopigmentation models of Hermansky-Pudlak syndrome (HPS), and 9 of these have been characterized at the molecular level. Zhang et al. (2003) used positional candidate and transgenic rescue approaches to identify the genes mutated in ruby-eye-2 (ru2) and ruby-eye (ru), 2 'mimic' mouse models of HPS. They determined that these genes are orthologs of the human genes mutated in individuals with HPS5 and HPS6, respectively. Both genes are found only in higher eukaryotes. The human ru ortholog contains 775aa and is 80% identical to the mouse protein. Northern blot analysis of mouse tissues detected a 2.6kb ru transcript in all tissues tested, with lowest expression in skeletal muscle. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.