CXCR3 (Chemokine C-X-C-Motif Receptor 3, CD183, CKR-L2, CMKAR3, GPR9, IP10r, IP10-R, Mig-R, MigR, G Protein-Coupled Receptor 9, Interferon-inducible protein 10 receptor, IP-10 receptor)

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£482.00

SKU:: 369493
Reinheit:: Purified by immunoaffinity chromatography.
Lagerbedingungen:: -20°C
Hersteller:: United States Biological
Host:: Rabbit
Format:: Supplied as a liquid in PBS, pH 7.4, 0.02% sodium azide, 50% glycerol.
Weitere Details:: CD183 (CXCR3) is a multi-pass type-3, 7 span 368aa glycoprotein. It contains an extracellular domain which contains 3 potential amino-glycosylation sites, 7 putative transmembrane-spanning domains and an intracellular C-terminal regions which has 3 intracellular loop regions. The intracellular C-terminal region contains 10 Thr/Ser residues that may become phosphorylated during CD183-mediated signaling. The DRYLAIVHA-motif in the 2nd intracellular loop is the most highly conserved sequence element in chemokine receptors. CD183 is a chemokine receptor which are G-proteins coupled receptors. CD183 shares a 30% identity with CD181 (CXCR1) and CD182 (CXCR2). Applications: Suitable for use in ELISA, Western Blot, Immunoprecipitation, Immunohistochemistry, Immunocytochemistry. Other applications not tested. Recommended Dilution: ELISA: 1:100-1:5000 Western Blot: 1:50-400 Immunohistochemistry (frozen): 1:50-500 Immunohistochemistry (paraffin): 1:10-100 Immunocytochemistry: 1:50-500 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Versandbedingungen:: Blue Ice