368506
CD40L (CD40 Ligand, CD154, Tumor Necrosis Factor Ligand Superfamily Member 5, TNFSF5, Gp39, TRAP)
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£576.00
- SKU:
- 368506
- Reinheit:
- Purified by Protein A affinity chromatography. Endotoxin: ≤0.001EU/ug
- Lagerbedingungen:
- -20°C
- Hersteller:
- United States Biological
- Host:
- Human
- Immunogen:
- Recombinant protein corresponding to human CD40L
- Klon:
- hu5c8
- Format:
- Supplied as a liquid in PBS. No preservative added.
- Weitere Details:
- CD40 Ligand (CD40L), renamed TNFSF5 but now also known as CD154, TRAP and gp39, is a 34-39kD type II transmembrane glycoprotein, that belongs to the TNF superfamily, and a surface receptor expressed on activated T cells which acts as a costimulatory molecule to trigger immune responses. CD40L binds to CD40, which is essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development and germinal center formation. CD40 is constitutively expressed by antigen presenting cells, including dendritic cells, B cells and macrophages. Consistent with its widespread expression on normal cells, CD40 is also expressed on a wide range of tumor cells. CD40L levels are increased in serum and in inflamed tissues of patients with autoimmune diseases. Applications: Suitable for use in Flow Cytometry, Western Blot and Blocking. Other applications not tested. Recommended Dilutions: Flow Cytometry: 1ug/ml Blocking: Neutralizes CD40L function by blocking the interaction between CD40 and CD40L in vitro and in vivo. Western Blot: 1ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
- Versandbedingungen:
- Blue Ice