LY2157299 (LY 2157299, LY-2157299, Galunisertib)

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£349.00

SKU:: 366899
Molekulargewicht:: 369.4
Reinheit:: Highly Purified (~98%)
Lagerbedingungen:: -20°C
Hersteller:: United States Biological
CAS Number:: 700874-72-2
Format:: Supplied as a crystalline solid.
Weitere Details:: Synonyms: LY 2157299, LY-2157299, Galunisertib Chemical Name: 4-[2-(6-methylpyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl]quinoline-6-carboxamide Molecular Formula: C22 H19 N5 Molecular Weight: 369.4 CAS Number: 700874-72-2 Purity: ≥98% Applications: FA Appearance: Crystalline solid Description: LY2157299 is a potent inhibitor of Transforming Growth factor-Beta Receptor I (TGF-BetaR). TGF-Beta1 is involved in the control of cell growth, proliferation, differentiation, and apoptosis. LY2157299 is reported to disrupt Smad-2 phosphorylation in Human Umbilical Vein Endothelial Cells (HUVEC) and inhibit the growth and migration of tumor cells. Storage: Soluble in organic solvents such as ethanol and DMSO. DMSO up to 25mg/ml.