LGK974 (LGK-974, WNT-974, LGK 974, NVP-LGK974)

Größe

£314.00

SKU:: 366896
Molekulargewicht:: 396.44
Lagerbedingungen:: 4°C
Hersteller:: United States Biological
CAS Number:: 1243244-14-5
Weitere Details:: LGK974 is a highly potent inhibitor of Porcupine (PORCN), a Wnt-specific acyltransferase. LGK974 is orally bioavailable and inhibits WNT signaling in vitro and in vivo. It is reported to exhibit anti-tumor properties without increasing cytotoxicity Synonyms: 2-[5-methyl-6-(2-methylpyridin-4-yl)pyridin-3-yl]-N-(5-pyrazin-2-ylpyridin-2-yl)acetamide; LGK-974; WNT-974; LGK 974; NVP-LGK974; 2’,3-Dimethyl-N-[5-(2-pyrazinyl)-2-pyridinyl]-[2,4’-bipyridine]-5-acetamide; 2-(2’,3-Dimethyl-[2,4’-bipyridin]-5-yl)-N-(5-(pyrazin-2-yl)pyridin-2-yl)acetamide CAS Number: 1243244-14-5 Molecular Formula: C₂₃H₂₀N₆O Molecular Weight: 396.44 Purity (HPLC): ≥95% Appearance: Off-white to white solid Melting Point: 176-180°C (lit) Solubility: Chloroform (Slightly), Methanol (Slightly) Method for Determining Identity: Proton NMR Spectroscopic and Mass Spectrometric analysis TLC Conditions: SiO2; Dichloromethane: Methanol=9:1; Visualized with UV and AMCS; Single Spot, Rf=0.40 Water Content (KF): As Reported Storage and Stability: May be stored at RT for short-term only. Long-term storage is recommended at 4ºC for 6 months after receipt. For maximum recovery of product, centrifuge the original vial prior to removing the cap.