365435
TREM1 (Triggering Receptor Expressed On Myeloid Cells 1, CD354, Triggering Receptor Expressed On Monocytes-1)
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£513.00
- SKU:
- 365435
- Reinheit:
- Purified by Protein A and peptide affinity chromatography.
- Lagerbedingungen:
- -20°C
- Hersteller:
- United States Biological
- Host:
- Rabbit
- Immunogen:
- Recombinant protein corresponding to Ala22-Ser232 of bovine TREM1, expressed in E. coli.
- Format:
- Supplied as a liquid in 0.01M PBS, pH7.4, 0.05% Proclin-300, 50% glycerol.
- Weitere Details:
- TREM-1 is a Type I membrane protein that contains an immunoglobulin-like V-type domain. An alternatively spliced protein variant may be secreted. TREM-1 is expressed in monocytes and neutrophils but not in lymphocytes, dendritic cells or other cell types. TREM1 expression can be further upregulated by bacteria, fungi and lipopolysaccharide. TREM-1 is a glycoprotein that is reduced by deglycosylation, in agreement with the predicted molecular mass. TREM-1 is an activating receptor of the Ig superfamily that is highly expressed on peripheral blood myeloid cells (particularly mature monocytes and granulocytes). TREM1 has been shown to interact with the adaptor protein DAP12 to stimulate neutrophil and monocyte-mediated inflammatory responses through the triggering and release of pro-inflammatory cytokines and chemokines. Applications: Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. AA Sequence: MGSSHHHHHH SSGLVPRGSH MASMTGGQQM GRGS- AEVFEEKCT LAEGQTLKVS CPTNTNIYSN SQKAWQRLKD NGEVQTLAIT EGSSQVRVGK YFLEDIPSEG MLQIQMANLQ VEDSGLYRCV ILGPSDPIIL FHPVRLVVTK NSLGTPASDE YPCQVSVQNP TPLPVTTKLR PRPRPRPKPV TQPIPTSADR LSSPGFTVTP TNVTHVNRAP GISIIIPAAC GLLSKTLVFI GLFAVTHRSF AS Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
- Versandbedingungen:
- Blue Ice