365244
TCN1 (Transcobalamin I, TCI, TC1, Haptocorin, Haptocorrin, Vitamin B12 Binding Protein,R Binder Family)
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£626.00
- SKU:
- 365244
- Anwendung:
- WB
- Reinheit:
- Purified by Protein A and peptide affinity chromatography.
- Lagerbedingungen:
- -20°C
- Hersteller:
- United States Biological
- Host:
- Rabbit
- Immunogen:
- Recombinant protein corresponding to Glu24-Tyr433 of human TCN1, expressed in E. coli.
- Format:
- Supplied as a liquid in 0.01M PBS, pH 7.4, 0.05% Proclin-300, 50% glycerol.
- Weitere Details:
- There are 3 types of human vitamin B12-binding proteins: gastric intrinsic factor (GIF), also known as transcobalamin III; plasma transcobalamin II (TCN2); and transcobalamin I (TCN1), an R binder protein. R binder proteins are a class of immunologically identical but electrophoretically distinct glycoproteins found in many secretions, such as saliva, gastric juice, tears, milk and leukocytes, and differ only in their carbohydrate content; 'R' denotes 'rapid,' referring to electrophoretic mobility. Transcobalamin I is also found in neutrophils, where it is restricted to the secondary granules. The deduced 433-residue protein showed extensive areas of homology with rat gastric intrinsic factor, which implicated regions potentially important for vitamin B12 binding. Comparison of the genomic structures of TCN1 and GIF suggested that the 2 genes arose by a gene duplication. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap
- Versandbedingungen:
- Blue Ice