365243
TCL1A (T-Cell Leukemia/Lymphoma Protein 1A, Tgtp, TCL1A, TCL1, T-Cell Specific GTPase, Oncogene TCL1, Protein p14 TCL1)
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£524.00
- SKU:
- 365243
- Anwendung:
- WB
- Reinheit:
- Purified by Protein A and peptide affinity chromatography.
- Lagerbedingungen:
- -20°C
- Hersteller:
- United States Biological
- Host:
- Rabbit
- Immunogen:
- Recombinant protein corresponding to Met1-Asp114 of human TCL1A, expressed in E. coli.
- Format:
- Supplied as a liquid in 0.01M PBS, pH 7.4, 0.05% Proclin-300, 50% glycerol.
- Weitere Details:
- TCL1, is situated at 14q32.3 and is activated when it comes into juxtaposition with the TCRA locus with inversion;. Erikson et al. showed that the TCRA locus is split between the proximal V gene and the more distal C gene by the breakpoint at 14q11.2 that creates of T-cell leukemia. Mathieu-Mahul et al. cloned a DNA fragment from 14q11 in a case of T-cell malignancy. Mengle-Gaw et al. and Davey et al. both studied chromosome rearrangements, inversions, or translocations, involving 14q in patients with ataxia-telangiectasia. These patients are prone to the development of lymphatic neoplasms in association with these abnormalities. Mengle-Gaw et al. concluded that a single locus at chromosome band 14q32.1, located about 15-20 million basepairs centromeric to the IGH locus, is critical to the development of neoplasia. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. AA Sequence: MGSSHHHHHH SSGLVPRGSH MASMTGGQQM GRGSEF- MAECPTLGEA VTDHPDRLWA WEKFVYLDEK QHAWLPLTIE IKDRLQLRVL LRREDVVLGR PMTPTQIGPS LLPIMWQLYP DGRYRSSDSS FWRLVYHIKI DGVEDMLLEL LPDD Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap
- Versandbedingungen:
- Blue Ice