365191
STAP1 (Signal Transducing Adaptor Protein 1, BRDG1, STAP1, BCR Downstream Signaling 1, Docking protein BRDG1, Stem cell adaptor protein 1)
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£577.00
- SKU:
- 365191
- Reinheit:
- Purified by Protein A and peptide affinity chromatography.
- Lagerbedingungen:
- -20°C
- Hersteller:
- United States Biological
- Host:
- Rabbit
- Immunogen:
- Recombinant protein corresponding to Met1-Ala297 of rat STAP1, expressed in E. coli.
- Format:
- Supplied as a liquid in 0.01M PBS, pH7.4, 0.05% Proclin-300, 50% glycerol.
- Weitere Details:
- STAP1 functions as a docking protein acting downstream of Tec tyrosine kinase in B cell antigen receptor signaling. The protein is directly phosphorylated by Tec in vitro where it participates in a positive feedback loop, increasing Tec activity. A mouse ortholog, stem cell adaptor protein 1, shares 83% identity with its human counterpart. The BRDG1 open reading frame encodes a protein of 295aa. The overall structure of BRDG1 resembles those of docking proteins such as IRS1, IRS2, DOK1, or DOC2. BRDG1 is phosphorylated by TEC directly in vitro. Studies revealed, furthermore, that BRDG1 appears to function as a docking protein acting downstream of TEC in BCR signaling. Applications: Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
- Versandbedingungen:
- Blue Ice