365172
SRPK2 (SRSF Protein Kinase 2, SFRSK2, SFRS Protein Kinase 2, Serine/arginine-rich protein-specific kinase 2)
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£626.00
- SKU:
- 365172
- Reinheit:
- Purified by Protein A and peptide affinity chromatography.
- Lagerbedingungen:
- -20°C
- Hersteller:
- United States Biological
- Host:
- Rabbit
- Immunogen:
- Recombinant protein corresponding to Glu380-Leu617 of human SRPK2, expressed in E. coli.
- Format:
- Supplied as a liquid in 0.01M PBS, pH7.4, 0.05% Proclin-300, 50% glycerol.
- Weitere Details:
- Pre-mRNA splicing is a critical step in the posttranscriptional regulation of gene expression. This process requires small nuclear ribonucleoprotein particles (snRNPs) and non-snRNP splicing factors, both of which are stored in nuclear 'speckles.' Non-snRNP factors containing an arginine/serine-rich (RS) domain, designated 'SR proteins', are phosphorylated, predominantly on serines within their RS domains. The predicted Srpk2 protein contains conserved serine/threonine kinase domains, a proline-rich domain, a basic region which may be a nuclear localization signal, and an acidic domain. The mouse Srpk2 protein is 58% and 32% identical to the human SRPK1 and yeast Dsk1 proteins, respectively. The authors demonstrated that Srpk2 phosphorylated ASF/SF2 in vitro. Applications: Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. AA Sequence: MGSSHHHHHH SSGLVPRGSH MASMTGGQQM GRGSEF- E LANIDPTWIE SPKTNGHIEN GPFSLEQQLD DEDDDEEDCP NPEEYNLDEP NAESDYTYSS SYEQFNGELP NGRHKIPESQ FPEFSTSLFS GSLEPVACGS VLSEGSPLTE QEESSPSHDR SRTVSASSTG DLPKAKTRAA DLLVNPLDPR NADKIRVKIA DLGNACWVHK HFTEDIQTRQ YRSIEVLIGA GYSTPADIWS TACMAFELAT GDYLFEPHSG EDYSRDEDHI AHIIELL Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
- Versandbedingungen:
- Blue Ice