365123
SOD1 (Superoxide Dismutase 1, Soluble, ALS, ALS1, IPOA, Amyotrophic Lateral Sclerosis 1, Adult, Superoxide dismutase [Cu-Zn])
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£523.00
- SKU:
- 365123
- Reinheit:
- Purified by immunoaffinity chromatography.
- Lagerbedingungen:
- -20°C
- Hersteller:
- United States Biological
- Host:
- Rabbit
- Immunogen:
- Recombinant protein corresponding to Ala2-Gln153 of porcine SOD1, expressed in E. coli.
- Format:
- Supplied as a liquid in PBS, pH 7.4, 0.02% sodium azide, 50% glycerol.
- Weitere Details:
- Superoxide dismutase 1, solubleis a human protein and gene. This gene encodes one of three forms of the human superoxide dismutase. SOD1 binds copper and zinc ions and is one of three isozymes responsible for destroying free superoxide radicals in the body. The encoded isozyme is a soluble cytoplasmic and mitochondrial intermembrane space protein, acting as a homodimer to convert naturally occurring, but harmful, superoxide radicals to molecular oxygen and hydrogen peroxide. Mutations (over 100 identified to date) in this gene have been linked to familial amyotrophic lateral sclerosis. The most frequent mutation are A4V (in the U.S. A.) and H46R (Japan). The most studied ALS mouse model is G93A. Rare transcript variants have been reported for this gene. Applications: Suitable for use in ELISA, Western Blot, Immunohistochemistry, Immunocytochemistry. Other applications not tested. Recommended Dilution: ELISA: 1:100-1:5000 Western Blot: 1:50-400 Immunohistochemistry (frozen): 1:50-500 Immunohistochemistry (paraffin): 1:10-100 Immunocytochemistry: 1:50-500 Optimal dilutions to be determined by the researcher. AA Sequence: MGSSHHHHHH SSGLVPRGSH MASMTGGQQM GRGS- ATKAVCVLK GDGPVQGTIY FELKGEKTVL VTGTIKGLAE GDHGFHVHQF GDNTQGCTSA GPHFNPESKK HGGPKDQERH VGDLGNVTAG KDGVATVYIE DSVIALSGDH SIIGRTMVVH EKPDDLGRGG NEESTKTGNA GSRLACGVIG ITQ Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
- Versandbedingungen:
- Blue Ice