365121
SOCS3 (Suppressors Of Cytokine Signaling 3, ATOD4, CIS3, Cish3, MGC71791, SOCS-3, SSI-3, SSI3, Cytokine-inducible SH2 protein 3, STAT-induced STAT inhibitor 3)
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£524.00
- SKU:
- 365121
- Anwendung:
- WB
- Reinheit:
- Purified by Protein A and peptide affinity chromatography.
- Lagerbedingungen:
- -20°C
- Hersteller:
- United States Biological
- Host:
- Rabbit
- Immunogen:
- Recombinant protein corresponding to Met1-Leu225 of human SOCS3, expressed in E. coli.
- Format:
- Supplied as a liquid in PBS, pH 7.4, 0.02% sodium azide, 50% glycerol.
- Weitere Details:
- SOCS-3 is an SH2-containing protein that binds to the activation loop of Janus kinases, inhibiting kinase activity and thereby suppressing cytokine signaling. It is a member of the STAT-induced STAT inhibitor (SSI). To date, there are eight members of SOCS family that have been recognized. Structurally, the SOCS proteins are composed of an N terminal region of variable length and amino acid composition, a central SH2 domain and a previously unrecognized C-terminal motif that has been called the SOCS box. The expression of the SOCS-3 gene is induced by various cytokines, including IL-6, IL-10, and interferon (IFN)-gamma. Studies of the mouse counterpart of the SOCS-3 gene suggested this gene is involved in the negative regulation of fetal liver hematopoiesis, and placental development. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
- Versandbedingungen:
- Blue Ice