364931
Rock1 (Rho Associated Coiled Coil Containing Protein Kinase 1, p160ROCK, Rho-associated protein kinase 1, Renal carcinoma antigen NY-REN-35)
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£537.00
- SKU:
- 364931
- Reinheit:
- Purified by Protein A and peptide affinity chromatography.
- Lagerbedingungen:
- -20°C
- Hersteller:
- United States Biological
- Host:
- Rabbit
- Immunogen:
- Recombinant protein corresponding to Leu1094-Gly1323 of mouse Rock1, expressed in E. coli.
- Format:
- Supplied as a liquid in PBS, pH 7.4, 0.02% sodium azide, 50% glycerol.
- Weitere Details:
- ROCK1, is a protein serine/threonine kinase, It is activated when bound to the GTP-bound form of Rho GTPase. This protein is thus a downstream effector of Rho. It phosphorylates and activates LIM kinase, which in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. Thus, ROCK1 contributes to actin-stability.In a study of the expression of ROCK1 during the cell cycle of the corneal epithelium, they found that levels of ROCK1 were significantly lower in the G1 phase than in the S and G0 phases. Downregulation of ROCK1 during the G1 phase is due in part to the decreased levels of its mRNA. The authors concluded that ROCK1 may have a role in the progression of the cell cycle in the corneal epithelial cells as they migrate centripetally from the limbus across the corneal surface. Applications: Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. AA Sequence: MGSSHHHHHH SSGLVPRGSH MASMTGGQQM GRGS- LLDLSDS TSVASFPSAD ETDGNLPESR IEGWLSVPNR GNIKRYGWKK QYVVVSSKKI LFYNDEQDKE QSSPSMVLDI DKLFHVRPVT QGDVYRAETE EIPKIFQILY ANEGECRKDI EVEPVQQGEK TNFQNHKGHE FIPTLYHFPA NCEACAKPLW HVFKPPPALE CRRCHVKCHR DHLDKKEDLI SPCKVSYDVT SARDMLLLAC SQDEQKKWVT HLVKKIPKNP PSG Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
- Versandbedingungen:
- Blue Ice