364909
RIPK1 (Receptor Interacting Serine Threonine Kinase 1, RIP, Receptor-Interacting Protein, Cell death protein RIP, Serine/threonine-protein kinase RIP)
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£626.00
- SKU:
- 364909
- Reinheit:
- Purified by Protein A and peptide affinity chromatography.
- Lagerbedingungen:
- -20°C
- Hersteller:
- United States Biological
- Host:
- Rabbit
- Immunogen:
- Recombinant protein corresponding to Phe17-Tyr289 of human RIPK1, expressed in E. coli.
- Format:
- Supplied as a liquid in PBS, pH 7.4, 0.02% sodium azide, 50% glycerol.
- Weitere Details:
- Two cell surface cytokine receptors, FAS and tumor necrosis factor (TNF) receptor, trigger apoptosis by natural ligands or specific agonist antibodies. Both receptors contain a conserved intracellular death domain. Using a yeast 2-hybrid screen with the cytoplasmic domain of FAS as bait, Stanger et al. (1995) isolated partial cDNAs encoding a receptor-interacting protein which they designated RIP. They used the partial cDNAs to isolate mouse cDNAs corresponding to the entire Rip coding region. Hsu et al. (1996) isolated a full-length human RIP cDNA. They reported that the predicted 671aa RIP protein contains an N-terminal protein kinase domain, a C-terminal death domain, and a unique internal region that they called the intermediate domain. Applications: Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
- Versandbedingungen:
- Blue Ice