364652
PK2 (Prokineticin 2, PK-2, Bv8, MIT1, KAL4, Protein Bv8 Homolog)
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£581.00
- SKU:
- 364652
- Reinheit:
- Purified by Protein A and peptide affinity chromatography
- Lagerbedingungen:
- -20°C
- Hersteller:
- United States Biological
- Host:
- Rabbit
- Immunogen:
- Recombinant protein corresponding to Thr30-Ser118 of mouse PK2 expressed in E. coli.
- Format:
- Supplied as a liquid in PBS, pH 7.4, 0.02% sodium azide, 50% glycerol.
- Weitere Details:
- Prokineticin 2 is a novel 81aa peptide with a complex folding structure including five disulphide linkages. It is a mammalian homolog to the mamba snake venom protein mamba intestinal toxin 1 and the frog protein Bv8, and has been demonstrated to be a paracrine mediator of gastrointestinal smooth muscle contractility.PK2 is expressed throughout the mammalian organism; however, in the brain, its expression is specifically concentrated in the suprachiasmatic nucleus (SCN). PK2 is rhythmically expressed in the SCN, transcriptionally regulated by clock control genes, and has the capacity to strongly suppress nocturnal locomotor activity. PK2 is one of the first neuropeptides that appears to directly convey circadian rhythm signaling to other CNS structures and, therefore, it may be a critical output molecule regulating biological rhythms. Applications: Suitable for use in ELISA, Western Blot, Immunohistochemistry and Immunocytochemistry. Other applications not tested. Recommended Dilutions: Western Blot: 0.5-2ug/ml Immunohistochemistry (Paraffin): 5-20ug/ml Immunocytochemistry: 5-20ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
- Versandbedingungen:
- Blue Ice