364498
OXCT1 (3-Oxoacid Coenzyme A Transferase 1, OXCT, SCOT, Succinyl-CoA:3-Ketoacid-Coenzyme A Transferase 1,Mitochondrial, Somatic-type succinyl-CoA:3-oxoacid CoA-transferase)
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£626.00
- SKU:
- 364498
- Reinheit:
- Purified by Protein A and peptide affinity chromatography.
- Lagerbedingungen:
- -20°C
- Hersteller:
- United States Biological
- Host:
- Rabbit
- Immunogen:
- Recombinant protein corresponding to aa40-489 of human OXCT1, expressed in E. coli.
- Format:
- Supplied as a liquid in PBS, pH 7.4, 0.05% Proclin-300, 50% glycerol.
- Weitere Details:
- OXCT1encodes a member of the 3-oxoacid CoA-transferase gene family. The encoded protein is a homodimeric mitochondrial matrix enzyme that plays a central role in extrahepatic ketone body catabolism by catalyzing the reversible transfer of coenzyme A from succinyl-CoA to acetoacetate. Mutations in this gene are associated with succinyl CoA:3-oxoacid CoA transferase deficiency.OXCT1 is a mitochondrial matrix enzyme that functions as a homodimer. From human heart cDNA libraries, Kassovska-Bratinova et al. (1996) cloned cDNAs spanning the entire 1,560-bp coding sequence using pig heart OXCT1 cDNA as a probe. They reported that a single mRNA transcript of 3.2kb was present in human tissues. OXCT1 mRNA was most abundant in heart and was also detectable in leukocytes and fibroblasts. Applications: Suitable for use in Immunohistochemistry, Western Blot and Immunofluorescence/Immunocytochemistry. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
- Versandbedingungen:
- Blue Ice