363918
LAT2 (Linker For Activation Of T-Cells Family, Member 2, WBSCR15, WBSCR5, WSCR5, HSPC046, LAB, NTAL, Williams-Beuren Syndrome Chromosome Region 5, Linker For Activation Of B Cells, Non-T Cell Activation Linker)
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£522.00
- SKU:
- 363918
- Reinheit:
- Purified by immunoaffinity chromatography.
- Lagerbedingungen:
- -20°C
- Hersteller:
- United States Biological
- Host:
- Rabbit
- Immunogen:
- Recombinant protein corresponding to Cys29-Val193 of mouse LAT2 expressed in E. coli.
- Format:
- Supplied as a liquid in PBS, pH 7.4, 0.02% sodium azide, 50% glycerol.
- Weitere Details:
- LAT2 is one of the contiguous genes at 7q11.23 commonly deleted in Williams syndrome, a multisystem developmental disorder. This gene consists of at least 14 exons, and its alternative splicing generates 3 transcript variants, all encoding the same protein. Sequence analysis predicted that human WBSCR5 is a 243aa nuclear protein, only 48% identical to the mouse sequence, that contains no known motifs. Northern blot analysis detected strong expression of a 1.9kb transcript in peripheral blood leukocytes, placenta, and lung, with lower expression in spleen, heart, brain, liver, and pancreas.NTAL associated with GRB2, SOS1, and GAB1 after B-cell receptor activation. Phosphorylation of NTAL was strongest in the presence of LCK, ZAP70, SYK, or LYN. Applications: Suitable for use in ELISA, Western Blot, Immunohistochemistry, Immunocytochemistry. Other applications not tested. Recommended Dilution: ELISA: 1:100-5000 Western Blot: 1:50-400 Immunohistochemistry (frozen): 1:50-500 Immunohistochemistry (paraffin): 1:10-100 Immunocytochemistry: 1:50-500 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
- Versandbedingungen:
- Blue Ice