363782
ITGa8 (Integrin Alpha 8, ITG-A8)
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£626.00
- SKU:
- 363782
- Anwendung:
- WB
- Reinheit:
- Purified by Protein A and peptide affinity chromatography.
- Lagerbedingungen:
- -20°C
- Hersteller:
- United States Biological
- Host:
- Rabbit
- Immunogen:
- Recombinant protein corresponding to aa907-1063 of human ITGa8 expressed in E. coli.
- Format:
- Supplied as a liquid in PBS, pH 7.4, 0.02% sodium azide, 50% glycerol.
- Weitere Details:
- Mechanosensory hair cells within the neuroepithelia of the cochlea and vestibule have stereocilia that are indispensable for mechanosensation. Evans and Muller (2000) demonstrated that integrin alpha-8/beta-1, its ligand fibronectin, and the integrin-regulated focal adhesion kinase colocalize to the apical hair cell surface where stereocilia are forming. In mice homozygous for a targeted mutation of integrin alpha-8, the colocalization is perturbed, and hair cells in the utricle, a vestibular subcompartment, lack stereocilia or contain malformed stereocilia. Most integrin alpha-8/beta-1-deficient mice die soon after birth due to kidney defects. Many of the surviving mice have difficulty balancing, consistent with the structural defects of the inner ear. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilutions: Western Blot: 0.01-2ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
- Versandbedingungen:
- Blue Ice