GZMH (Granzyme H, CCP-X, CGL-2, CSP-C, CTLA1, CTSGL2, Cathepsin G-Like 2,Protein h-CCPX, Cytotoxic T-lymphocyte proteinase, Cytotoxic serine protease C)

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£517.00

SKU:: 363402
Reinheit:: Purified by Protein A and peptide affinity chromatography.
Lagerbedingungen:: -20°C
Hersteller:: United States Biological
Host:: Rabbit
Immunogen:: Recombinant protein corresponding to Glu19-Leu246 of human GZMH, expressed in E. coli.
Format:: Supplied as a liquid in PBS, pH 7.4, 0.02% sodium azide, 50% glycerol.
Weitere Details:: GZMH is located in a cluster on 14q11.2 with cathepsin G and CTSGL1. A similar cluster of genes in the mouse is located on chromosome 14 near the TCRA locus. Granzymes are serine proteases that are released by cytoplasmic granules within cytotoxic T cells and natural killer cells. Their purpose is to induce apoptosis within virus-infected cells, thus destroying them.Cytotoxic T cells and natural killer cells release a protein called perforin, which attacks the target cells. Researchers used to think that perforin creates pores within the cells, through which the granzymes can enter, inducing apoptosis. However, new evidence indicates that GrB complex can enter a cell through the mannose 6-phosphate receptor and is enclosed in a vesicle. Applications: Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Versandbedingungen:: Blue Ice